Ce cours a été conçu par Nicolas Peschanski et Barbara Villoing le 1er avril 2026.

Les éléments principaux de cette formation sont : anémie falciforme, douleur, crise vaso-occlusive, syndrome thoracique aigu, transfusion

Guidelines for the management of emergencies and critical illness in pediatric and adult patients with sickle cell disease.
Mekontso Dessap A,Dauger S,Khellaf M,Agbakou M,Agut S,Angoulvant F,Arlet JB,Aubron C,Baudin F,Boissier F,Bounaud N,Catoire P,Cecchini J,Chaiba D,Chauvin A,Chocron R,Douay B,Douillet D,Elenga N,Flechelle O,Gendreau S,Goddet S,Guenezan J,Habibi A,Heilbronner C,Koehl B,Le Borgne P,Le Conte P,Legras A,Levy M,Maitre B,Oberlin M,Oualha M,Peschanski N,Pirenne F,Pondarre C,Rambaud J,Razazi K,Rousseau G,Schirmann A,Thuret I,Valentino R,Voiriot G,Villoing B,Grimaud M,Jean S, Annals of intensive care 2025 May 29 15(1) 74

A randomized controlled trial comparing two vaso-occlusive episode (VOE) protocols in sickle cell disease (SCD).
Tanabe P,Silva S,Bosworth HB,Crawford R,Paice JA,Richardson LD,Miller CN,Glassberg J, American journal of hematology 2018 Feb 93(2) 159-168

Patient-controlled analgesia versus continuous infusion of morphine during vaso-occlusive crisis in sickle cell disease, a randomized controlled trial.
van Beers EJ,van Tuijn CF,Nieuwkerk PT,Friederich PW,Vranken JH,Biemond BJ, American journal of hematology 2007 Nov 82(11) 955-60

A randomized, controlled clinical trial of ketoprofen for sickle-cell disease vaso-occlusive crises in adults.
Bartolucci P,El Murr T,Roudot-Thoraval F,Habibi A,Santin A,Renaud B,Noël V,Michel M,Bachir D,Galactéros F,Godeau B, Blood 2009 Oct 29 114(18) 3742-7

Incentive spirometry to prevent acute chest syndrome in adults with sickle cell disease; a randomized controlled trial.
van Tuijn CFJ,Gaartman AE,Nur E,Rijneveld AW,Biemond BJ, American journal of hematology 2020 Jul 95(7) E160-E163

Fluid replacement therapy for acute episodes of pain in people with sickle cell disease.
Okomo U,Meremikwu MM, The Cochrane database of systematic reviews 2017 Jul 31 7(7) CD005406

Fluid overload due to intravenous fluid therapy for vaso-occlusive crisis in sickle cell disease: incidence and risk factors.
Gaartman AE,Sayedi AK,Gerritsma JJ,de Back TR,van Tuijn CF,Tang MW,Heijboer H,de Heer K,Biemond BJ,Nur E, British journal of haematology 2021 Sep 194(5) 899-907

Outcomes related to intravenous fluid administration in sickle cell patients during vaso-occlusive crisis.
Gaut D,Jones J,Chen C,Ghafouri S,Leng M,Quinn R, Annals of hematology 2020 Jun 99(6) 1217-1223

Bedside ultrasound as a predictive tool for acute chest syndrome in sickle cell patients.
Colla JS,Kotini-Shah P,Soppet S,Chen YF,Molokie R,Prajapati P,Prendergast HM, The American journal of emergency medicine 2018 Oct 36(10) 1855-1861

Utility of Point-of-Care Lung Ultrasonography for Evaluating Acute Chest Syndrome in Young Patients With Sickle Cell Disease.
Cohen SG,Malik ZM,Friedman S,Russell S,Hagbom R,Alazraki A,McCracken CE,Figueroa J,Adisa OA,Mendis RD,Manoranjithan S,Simon HK,Morris CR, Annals of emergency medicine 2020 Sep 76(3S) S46-S55

Elevated fibrin D-dimer fragment in sickle cell anemia: evidence for activation of coagulation during the steady state as well as in painful crisis.
Francis RB Jr, Haemostasis 1989 19(2) 105-11

A clinical risk score for pulmonary artery thrombosis during acute chest syndrome in adult patients with sickle cell disease.
Winchenne A,Cecchini J,Deux JF,De Prost N,Razazi K,Carteaux G,Galacteros F,Habibi A,Bartolucci P,Melica G,Khellaf M,Michel M,Maitre B,Mekontso Dessap A, British journal of haematology 2017 Nov 179(4) 627-634

Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease.
Mekontso Dessap A,Leon R,Habibi A,Nzouakou R,Roudot-Thoraval F,Adnot S,Godeau B,Galacteros F,Brun-Buisson C,Brochard L,Maitre B, American journal of respiratory and critical care medicine 2008 Mar 15 177(6) 646-53